Proteasome assembly

Across TCGA patient cohorts, RNA activity of the Proteasome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OTUD6B, NUDCD1, and DCAF13, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteasome assembly activity versus OTUD6B in COAD (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OTUD6B →	+0.460	+0.051	<.001	<.001	3	9
LUAD	NUDCD1 →	+0.283	+0.050	<.001	<.001	3	7
BRCA	DCAF13 →	+0.330	+0.047	<.001	.001	3	6
COAD	RIDA →	+0.611	+0.038	<.001	.001	3	5
OV	STK3 →	+0.465	+0.068	<.001	<.001	3	5
COAD	PHF20L1 →	+0.330	+0.043	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043248 vs OTUD6B — COAD

Explore this scatter interactively →