Proteasome assembly

Across TCGA patient cohorts, RNA activity of the Proteasome assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMTC1, KRT8P45, and MALSU1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteasome assembly activity versus TMTC1 in LSCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMTC1 →	-0.916	-0.092	.001	.006	3	4
BRCA	KRT8P45 →	+1.086	+0.197	<.001	.001	3	4
LUAD	MALSU1 →	+0.321	+0.135	<.001	<.001	3	4
BRCA	KRT8P30 →	+0.327	+0.154	.002	<.001	3	4
BRCA	ABCF2 →	+0.273	+0.126	.001	.002	3	4
LUAD	MDK →	+0.842	+0.129	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043248 vs TMTC1 — LSCC

Explore this scatter interactively →