Telomere maintenance in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Telomere maintenance in response to DNA damage pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP13_S2498, MSH2, and UBR7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance in response to DNA damage activity versus AKAP13_S2498 in GBM (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AKAP13_S2498 →	-0.429	-0.033	.001	<.001	3	7
LSCC	MSH2 →	+0.446	+0.034	.001	.001	3	5
HNSC	UBR7 →	+0.223	+0.043	<.001	.001	3	5
LUAD	SLX4IP_S396 →	+0.537	+0.030	<.001	.001	3	5
PDAC	TERF2_S365 →	+0.464	+0.029	.002	<.001	3	5
LSCC	PARN →	+0.241	+0.037	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043247 vs AKAP13_S2498 — GBM

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