Regulation of protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSX2, MMGT1, and MALT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSX2 grouped by Regulation of protein-containing complex disassembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MSX2 →	+1.754	+0.149	.003	.004	3	5
PANCREAS	MMGT1 →	-0.561	-0.308	.004	.003	3	4
PANCREAS	MALT1 →	-0.723	-0.228	.004	.006	3	4
LUNG_SCLC	FGFR1 →	-2.762	-0.210	<.001	<.001	3	4
SOFT_TISSUE	DNAJC16 →	-0.714	-0.233	<.001	<.001	3	4
SOFT_TISSUE	NDUFB6 →	+0.937	+0.272	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSX2 by Regulation of protein-containing complex disassembly activity — BREAST

Explore this box plot interactively →