Negative regulation of protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPA2, DBI, and MYBL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IMPA2 grouped by Negative regulation of protein-containing complex disassembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IMPA2 →	+1.038	+0.167	.001	.003	3	5
BLOOD_Myeloma	DBI →	+1.417	+0.357	<.001	.006	3	5
LARGE_INTESTINE	MYBL1 →	-0.972	-0.241	.002	.001	3	5
URINARY_TRACT	CKMT1A →	+4.682	+0.497	<.001	<.001	3	5
PANCREAS	RAB3D →	+1.226	+0.274	.009	.008	3	4
UPPER_AERODIGESTIVE_TRACT	SFXN3 →	-1.055	-0.189	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IMPA2 by Negative regulation of protein-containing complex disassembly activity — LARGE_INTESTINE

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