Negative regulation of protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO9A, SEL1L, and PHC3, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex disassembly activity versus MYO9A in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MYO9A →	+0.892	+0.050	<.001	<.001	3	17
BONE	SEL1L →	+1.213	+0.075	<.001	<.001	3	16
OVARY	PHC3 →	+1.318	+0.089	<.001	<.001	3	16
CNS	MAPK1 →	+1.041	+0.067	<.001	<.001	3	16
BLOOD_Lymphoma	LPP →	+1.752	+0.077	<.001	<.001	3	16
BLOOD_Lymphoma	ZNF148 →	+1.013	+0.057	<.001	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043242 vs MYO9A — BLOOD_Lymphoma

Explore this scatter interactively →