Negative regulation of protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTK1, NCK1, and STK40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex disassembly activity versus GSTK1 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GSTK1 →	+1.279	+0.372	.003	<.001	3	6
URINARY_TRACT	NCK1 →	+0.749	+0.383	.002	.002	3	4
LIVER	STK40 →	+1.000	+0.315	.003	.008	2	5
OESOPHAGUS	EEPD1 →	+1.469	+0.309	<.001	<.001	3	4
BLOOD_Myeloma	TES →	+1.323	+0.190	.005	.008	2	5
SKIN	FBXO7 →	+1.073	+0.191	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043242 vs GSTK1 — OESOPHAGUS

Explore this scatter interactively →