Myelin maintenance

Across TCGA patient cohorts, RNA activity of the Myelin maintenance pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, RRAS, and PLEC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myelin maintenance activity versus TMEM97 in PDAC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMEM97 →	-1.079	-0.437	<.001	<.001	3	6
GBM	RRAS →	+0.491	+0.334	.001	.004	3	6
LUAD	PLEC →	+0.769	+0.319	<.001	<.001	3	6
HNSC	IGFL2 →	+1.334	+0.336	.001	<.001	3	6
LSCC	LGALS1 →	+0.964	+0.776	<.001	.001	3	5
PDAC	TIMP3 →	+0.769	+0.284	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043217 vs TMEM97 — PDAC

Explore this scatter interactively →