Myelin maintenance

Across TCGA cell cohorts, RNA activity of the Myelin maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD1, DHRS11, and ERCC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOD1 grouped by Myelin maintenance-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SOD1 →	-0.408	-1.080	<.001	<.001	3	9
SKIN	DHRS11 →	-0.191	-1.007	.001	.004	3	5
LUNG_NSCLC_LUAD	ERCC2 →	-0.226	-0.722	.004	.001	3	4
LUNG_NSCLC_LUAD	DMGDH →	-0.127	-0.725	.002	.002	3	4
KIDNEY	DDX23 →	+0.281	+0.811	.001	.001	3	4
SKIN	POU2F3 →	-0.180	-1.036	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOD1 by Myelin maintenance activity — SKIN

Explore this box plot interactively →