Myelin maintenance

Across TCGA cell cohorts, RNA activity of the Myelin maintenance pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD1, HIF1AN, and OGDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myelin maintenance activity versus SAMD1 in OVARY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SAMD1 →	-0.795	-0.187	.003	.001	3	6
OESOPHAGUS	HIF1AN →	-1.066	-0.273	.002	.006	3	5
OESOPHAGUS	OGDH →	-1.125	-0.345	.007	.002	3	5
SOFT_TISSUE	MEGF8 →	-1.144	-0.344	.003	<.001	3	5
OESOPHAGUS	RBM12 →	-0.734	-0.253	.007	.009	3	5
OVARY	DBNL →	-0.574	-0.195	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043217 vs SAMD1 — OVARY

Explore this scatter interactively →