Response to L-leucine

Across TCGA patient cohorts, RNA activity of the Response to L-leucine pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTR5A-AS1, SMUG1, and FRG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-leucine activity versus HTR5A-AS1 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HTR5A-AS1 →	+0.016	+0.159	<.001	<.001	3	3
LUAD	SMUG1 →	-0.274	-0.507	.004	.003	3	3
BRCA	FRG1 →	-0.202	-0.247	.008	.001	3	2
BRCA	KCNMB1 →	-0.396	-0.322	.003	.001	3	2
BRCA	CNPY4 →	-0.287	-0.218	.009	.005	3	2
BRCA	LRRC8E →	+0.215	+0.222	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043201 vs HTR5A-AS1 — OV

Explore this scatter interactively →