Response to L-leucine

Across TCGA patient cohorts, RNA activity of the Response to L-leucine pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPM1F_S454, ARHGEF17_S1681, and SCAF11_S401, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-leucine activity versus PPM1F_S454 in OV (Pearson r = -0.86).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPM1F_S454 →	-1.968	-0.346	<.001	<.001	3	3
BRCA	ARHGEF17_S1681 →	+1.457	+0.915	<.001	.007	3	3
GBM	SCAF11_S401 →	+0.623	+0.273	<.001	<.001	3	2
GBM	TBCCD1 →	-0.737	-0.494	<.001	.001	3	2
UCEC	TJP1_T868 →	+1.004	+0.642	<.001	<.001	3	2
GBM	TNRC6B_S1539 →	+0.719	+0.254	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043201 vs PPM1F_S454 — OV

Explore this scatter interactively →