Response to L-leucine

Across TCGA cell cohorts, RNA activity of the Response to L-leucine pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC27, RPL22, and USP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC27 grouped by Response to L-leucine-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC27 →	-0.254	-0.052	.002	.006	3	4
SOFT_TISSUE	RPL22 →	-0.277	-0.100	.005	<.001	3	4
SOFT_TISSUE	USP7 →	+0.491	+0.145	<.001	<.001	3	4
SOFT_TISSUE	UGT1A10 →	+0.268	+0.078	.002	.007	3	4
SOFT_TISSUE	GAN →	-0.378	-0.094	<.001	.002	3	4
BLOOD_Myeloma	H1-9P →	-0.161	-0.087	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC27 by Response to L-leucine activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →