Nucleoside salvage

Across TCGA patient cohorts, RNA activity of the Nucleoside salvage pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPGRIP1L, TRDMT1, and ARL13B, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside salvage activity versus RPGRIP1L in TGCT (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	RPGRIP1L →	+0.692	+0.049	<.001	<.001	3	29
UCS	TRDMT1 →	+0.564	+0.056	<.001	<.001	3	29
UCS	ARL13B →	+0.879	+0.052	.005	.002	1	31
ACC	ITGB1 →	+1.340	+0.056	<.001	<.001	3	29
UVM	PTPDC1 →	+0.885	+0.053	<.001	<.001	3	29
ACC	ADAT1 →	+0.758	+0.053	.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043174 vs RPGRIP1L — TGCT

Explore this scatter interactively →