Nucleoside salvage

Across TCGA patient cohorts, RNA activity of the Nucleoside salvage pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WWTR1-AS1, HSD17B14, and CDKN2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside salvage activity versus WWTR1-AS1 in COAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WWTR1-AS1 →	+0.117	+0.130	<.001	<.001	3	4
COAD	HSD17B14 →	+0.527	+0.106	<.001	.002	3	4
COAD	CDKN2A →	+0.663	+0.117	<.001	<.001	3	3
HNSC	CYSLTR1 →	+0.383	+0.055	.004	.002	3	3
COAD	ERC2 →	+0.162	+0.104	<.001	.008	3	3
COAD	LINC00592 →	+0.082	+0.102	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043174 vs WWTR1-AS1 — COAD

Explore this scatter interactively →