Nucleoside salvage

Across TCGA cell cohorts, RNA activity of the Nucleoside salvage pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP1, IFI6, and FBLN7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBP1 grouped by Nucleoside salvage-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RBP1 →	+3.220	+0.855	.007	.002	3	4
LARGE_INTESTINE	IFI6 →	+2.316	+0.731	.005	.005	3	4
CNS	FBLN7 →	+1.541	+0.875	.005	.003	3	4
OVARY	COL5A1 →	+2.482	+0.751	.003	.009	3	4
OESOPHAGUS	TGFBI →	+3.212	+0.617	.005	.007	2	4
OESOPHAGUS	LRRC39 →	+0.441	+1.022	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBP1 by Nucleoside salvage activity — STOMACH

Explore this box plot interactively →