Nucleoside salvage

Across TCGA cell cohorts, RNA activity of the Nucleoside salvage pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF16, PA2G4, and DNPH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside salvage activity versus KLF16 in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLF16 →	+0.977	+1.097	.002	.001	3	6
STOMACH	PA2G4 →	+1.179	+1.368	<.001	.001	3	6
SOFT_TISSUE	DNPH1 →	+1.474	+1.511	<.001	.002	3	5
SOFT_TISSUE	ANKRD16 →	+0.541	+1.360	.004	<.001	3	5
PANCREAS	SORD →	+1.009	+1.132	.009	.007	3	5
LUNG_NSCLC_LUSC	IGFBP6 →	-4.371	-1.426	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043174 vs KLF16 — STOMACH

Explore this scatter interactively →