Nucleotide salvage

Across TCGA patient cohorts, RNA activity of the Nucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFEC, IL2RA, and STX11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide salvage activity versus TFEC in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TFEC →	+0.920	+0.158	<.001	.001	2	6
HNSC	IL2RA →	+0.877	+0.160	<.001	<.001	2	6
UCEC	STX11 →	+0.494	+0.175	.005	.001	3	5
LSCC	NT5C3AP2 →	+0.523	+0.155	.005	.006	3	5
OV	LINC01934 →	+0.071	+0.227	.009	.005	3	5
BRCA	TMEM106A →	+0.364	+0.107	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043173 vs TFEC — HNSC

Explore this scatter interactively →