Nucleotide salvage

Across TCGA cell cohorts, RNA activity of the Nucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD33B, MTMR11, and CDC25C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD33B grouped by Nucleotide salvage-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANKRD33B →	-1.241	-0.826	<.001	<.001	3	4
SOFT_TISSUE	MTMR11 →	-1.775	-1.463	.007	<.001	3	3
SOFT_TISSUE	CDC25C →	+0.753	+1.303	.001	<.001	3	3
SOFT_TISSUE	STARD5 →	+1.132	+1.368	<.001	.002	3	3
SOFT_TISSUE	STARD6 →	-0.263	-1.289	<.001	<.001	3	3
SOFT_TISSUE	POLD3 →	+0.484	+0.998	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD33B by Nucleotide salvage activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →