Peptide catabolic process

Across TCGA patient cohorts, RNA activity of the Peptide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2_S723, RUVBL1, and CNPY4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide catabolic process activity versus DAB2_S723 in CCRCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DAB2_S723 →	+0.800	+0.039	.004	.008	3	8
LSCC	RUVBL1 →	-0.284	-0.062	<.001	<.001	3	7
LSCC	CNPY4 →	+0.426	+0.072	<.001	<.001	3	7
GBM	COPZ2 →	+0.498	+0.060	<.001	<.001	3	7
COAD	FAP →	+0.913	+0.047	<.001	<.001	3	7
GBM	IKBIP →	+0.560	+0.063	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043171 vs DAB2_S723 — CCRCC

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