Peptide catabolic process

Across TCGA patient cohorts, RNA activity of the Peptide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYVE1, DCTPP1, and F13A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide catabolic process activity versus LYVE1 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LYVE1 →	+1.155	+0.150	.001	.004	3	7
UCEC	DCTPP1 →	-0.892	-0.195	.004	.009	3	7
GBM	F13A1 →	+1.483	+0.173	.002	.001	3	6
GBM	FLI1 →	+0.718	+0.226	<.001	<.001	3	6
BRCA	SPARCL1 →	+1.033	+0.143	.002	<.001	3	6
OV	DDR2 →	+1.000	+0.131	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043171 vs LYVE1 — GBM

Explore this scatter interactively →