Induction of bacterial agglutination

Across TCGA patient cohorts, RNA activity of the Induction of bacterial agglutination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCB2, NCF2, and NNMT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Induction of bacterial agglutination activity versus PLCB2 in GBM (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCB2 →	+0.721	+0.394	<.001	<.001	3	7
COAD	NCF2 →	+0.631	+0.111	<.001	<.001	3	7
OV	NNMT →	+0.992	+0.129	<.001	<.001	3	6
GBM	TLR2 →	+0.500	+0.280	<.001	<.001	3	6
CCRCC	FCER1G →	+0.708	+0.206	<.001	<.001	3	6
GBM	HK3 →	+0.705	+0.266	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043152 vs PLCB2 — GBM

Explore this scatter interactively →