Induction of bacterial agglutination

Across TCGA cell cohorts, RNA activity of the Induction of bacterial agglutination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM83H, MAP3K1, and SEMA3G, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM83H grouped by Induction of bacterial agglutination-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM83H →	+2.342	+1.569	.003	<.001	3	4
BREAST	MAP3K1 →	+0.928	+0.932	<.001	.001	3	4
BLOOD_Leukemia	SEMA3G →	+1.222	+1.270	.001	<.001	3	4
LUNG_SCLC	MAST4 →	+1.500	+1.544	.005	.005	3	4
SOFT_TISSUE	MSRA →	+1.744	+1.711	.008	.002	3	4
BLOOD_Lymphoma	RSRC2 →	+1.140	+1.447	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM83H by Induction of bacterial agglutination activity — BLOOD_Leukemia

Explore this box plot interactively →