Stress fiber assembly

Across TCGA patient cohorts, RNA activity of the Stress fiber assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, ZCCHC24, and DAB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress fiber assembly activity versus RSU1 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.319	+0.033	<.001	<.001	3	9
OV	ZCCHC24 →	+0.936	+0.082	.002	<.001	3	9
GBM	DAB2 →	+0.544	+0.036	<.001	<.001	3	9
CCRCC	KANK2 →	+0.502	+0.044	<.001	<.001	3	9
GBM	PA2G4 →	-0.281	-0.056	<.001	<.001	3	9
CCRCC	DCN →	+0.783	+0.032	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043149 vs RSU1 — BRCA

Explore this scatter interactively →