Stress fiber assembly

Across TCGA cell cohorts, RNA activity of the Stress fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFF1, ZSWIM4, and TRIM36, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AFF1 grouped by Stress fiber assembly-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	AFF1 →	-1.025	-0.308	.001	.003	3	4
SKIN	ZSWIM4 →	-0.703	-0.215	.003	.002	2	5
LUNG_NSCLC_LUSC	TRIM36 →	-1.084	-1.266	.003	.008	3	3
BLOOD_Myeloma	UBA6 →	-1.143	-0.422	.003	<.001	3	3
SOFT_TISSUE	ALAS2 →	-0.075	-1.008	.008	<.001	3	3
OESOPHAGUS	GID8 →	-0.830	-1.185	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AFF1 by Stress fiber assembly activity — BLOOD_Myeloma

Explore this box plot interactively →