Stress fiber assembly

Across TCGA cell cohorts, RNA activity of the Stress fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFR1L, ZYX, and LACC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress fiber assembly activity versus MTFR1L in BREAST (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MTFR1L →	+0.710	+0.390	<.001	<.001	3	5
BLOOD_Leukemia	ZYX →	+3.262	+0.263	<.001	<.001	3	5
BLOOD_Leukemia	LACC1 →	+1.160	+0.240	.002	.001	3	5
BONE	ACTA2 →	+5.125	+0.533	.002	.006	3	4
BLOOD_Leukemia	VCL →	+1.301	+0.204	.003	.009	3	4
LUNG_SCLC	GAK →	-0.610	-0.220	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043149 vs MTFR1L — BREAST

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