Stress fiber assembly

Across TCGA cell cohorts, RNA activity of the Stress fiber assembly pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, TLN1, and CNN2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress fiber assembly activity versus ZYX in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZYX →	+2.787	+0.609	<.001	.007	3	16
URINARY_TRACT	TLN1 →	+2.363	+0.609	<.001	.007	3	14
PANCREAS	CNN2 →	+1.934	+0.998	<.001	.004	3	14
LUNG_NSCLC_LUAD	ARPC3 →	+0.978	+0.611	<.001	.002	3	13
LUNG_NSCLC_LUSC	SEPTIN7 →	+1.012	+0.432	.006	.008	3	13
PANCREAS	VCL →	+1.923	+1.126	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043149 vs ZYX — URINARY_TRACT

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