sno(s)RNA processing

Across TCGA patient cohorts, RNA activity of the sno(s)RNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEATR3, SLC12A9, and SSB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, sno(s)RNA processing activity versus HEATR3 in LUAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HEATR3 →	+0.296	+0.040	<.001	.002	3	6
LUAD	SLC12A9 →	-0.239	-0.039	.003	.003	3	5
LSCC	SSB →	+0.229	+0.046	.001	<.001	3	5
OV	TERF2IP →	+0.430	+0.066	<.001	<.001	3	5
LSCC	EDC4 →	+0.240	+0.055	<.001	<.001	3	5
OV	AARS1 →	+0.397	+0.048	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043144 vs HEATR3 — LUAD

Explore this scatter interactively →