sno(s)RNA processing

Across TCGA patient cohorts, RNA activity of the sno(s)RNA processing pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTH1R, SYNC, and C1QTNF7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, sno(s)RNA processing activity versus PTH1R in PDAC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PTH1R →	-0.556	-0.215	<.001	<.001	3	5
PDAC	SYNC →	-0.732	-0.225	<.001	<.001	3	5
BRCA	C1QTNF7 →	-0.787	-0.178	<.001	.002	3	5
LUAD	PLSCR4 →	-0.588	-0.162	<.001	.002	3	4
PDAC	PMP22 →	-0.559	-0.192	<.001	<.001	3	4
PDAC	FMOD →	-0.479	-0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043144 vs PTH1R — PDAC

Explore this scatter interactively →