sno(s)RNA processing

Across TCGA cell cohorts, RNA activity of the sno(s)RNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA1D, RALGAPA2, and FAM234B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACNA1D grouped by sno(s)RNA processing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CACNA1D →	-2.263	-0.172	.001	.007	3	4
LUNG_NSCLC_LUSC	RALGAPA2 →	-1.124	-0.202	<.001	<.001	3	3
LUNG_NSCLC_LUSC	FAM234B →	-0.685	-0.234	.001	.002	3	3
KIDNEY	GAS2L3 →	+1.089	+0.247	.004	.003	3	3
CNS	ACTR3B →	-0.741	-0.232	.002	.005	3	3
CNS	C17orf100 →	-0.601	-0.219	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACNA1D by sno(s)RNA processing activity — LUNG_SCLC

Explore this box plot interactively →