NAD transport

Across TCGA cell cohorts, RNA activity of the NAD transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALM3, DIPK2A, and MXD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PALM3 grouped by NAD transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PALM3 →	+1.531	+1.332	<.001	.002	3	4
SOFT_TISSUE	DIPK2A →	-1.662	-0.885	.003	.007	3	4
LARGE_INTESTINE	MXD4 →	-1.546	-1.417	.001	<.001	3	3
LARGE_INTESTINE	OARD1 →	-0.716	-1.440	.005	.001	3	3
LARGE_INTESTINE	RABGAP1L →	-1.140	-1.233	.002	.005	3	3
LUNG_NSCLC_LUAD	NIT2 →	+0.855	+0.852	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PALM3 by NAD transport activity — LARGE_INTESTINE

Explore this box plot interactively →