Surfactant homeostasis

Across TCGA patient cohorts, RNA activity of the Surfactant homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM14_S582, APOB, and CFH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Surfactant homeostasis activity versus RBM14_S582 in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RBM14_S582 →	-0.421	-0.071	<.001	<.001	3	7
OV	APOB →	+0.651	+0.057	.002	.003	3	7
OV	CFH →	+0.621	+0.046	.001	.007	3	7
GBM	MSI2 →	-0.338	-0.080	<.001	<.001	3	6
GBM	PSPC1 →	-0.424	-0.093	<.001	<.001	3	6
BRCA	CD93 →	+0.433	+0.053	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043129 vs RBM14_S582 — OV

Explore this scatter interactively →