Surfactant homeostasis

Across TCGA cell cohorts, RNA activity of the Surfactant homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGSM3, KHK, and PDE2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGSM3 grouped by Surfactant homeostasis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SGSM3 →	+0.843	+1.429	<.001	<.001	3	5
LUNG_NSCLC_LUSC	KHK →	+1.486	+1.432	.003	.001	3	5
LUNG_SCLC	PDE2A →	-2.678	-1.057	.002	.006	3	4
BLOOD_Leukemia	CMTM4 →	+1.044	+0.918	.004	.009	3	4
BLOOD_Leukemia	PGBD2 →	+0.613	+0.851	.003	.004	3	4
LIVER	MFSD9 →	+1.154	+1.346	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGSM3 by Surfactant homeostasis activity — LUNG_SCLC

Explore this box plot interactively →