Surfactant homeostasis

Across TCGA cell cohorts, RNA activity of the Surfactant homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNPEPL1, ZBTB3, and DDX17, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Surfactant homeostasis activity versus RNPEPL1 in OESOPHAGUS (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RNPEPL1 →	+1.363	+2.048	.002	<.001	3	3
OESOPHAGUS	ZBTB3 →	+0.859	+1.871	.007	<.001	3	3
OVARY	DDX17 →	+1.149	+1.904	<.001	<.001	3	2
OVARY	FNBP4 →	+0.919	+1.909	.007	<.001	3	2
OVARY	INO80D →	+0.996	+1.510	.001	<.001	3	2
OVARY	PLEKHA3 →	+1.128	+1.510	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043129 vs RNPEPL1 — OESOPHAGUS

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