Positive regulation of canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K7, DNAJB5, and PSG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K7 grouped by Positive regulation of canonical NF-kappaB signal transduction-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MAP3K7 →	-0.393	-0.158	<.001	<.001	3	6
STOMACH	DNAJB5 →	-0.220	-0.119	.003	.004	3	5
STOMACH	PSG1 →	-0.248	-0.159	.003	.007	3	5
LARGE_INTESTINE	SERPING1 →	-0.200	-0.165	.009	.007	3	5
CNS	CUL7 →	+0.180	+0.185	.007	.001	3	5
SKIN	CHRNB3 →	+0.179	+0.247	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K7 by Positive regulation of canonical NF-kappaB signal transduction activity — URINARY_TRACT

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