Positive regulation of canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGTB, FAM216A, and SEC61A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of canonical NF-kappaB signal transduction activity versus SGTB in CNS (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SGTB →	+0.566	+0.101	.004	.005	3	5
BLOOD_Myeloma	FAM216A →	+1.204	+0.147	<.001	<.001	3	4
SOFT_TISSUE	SEC61A2 →	+0.727	+0.161	.009	.004	3	4
STOMACH	SORL1 →	-2.400	-0.164	.003	.002	3	4
OVARY	SHC1 →	+1.438	+0.204	<.001	<.001	3	4
OVARY	TMEM158 →	+1.613	+0.175	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043123 vs SGTB — CNS

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