Negative regulation of vascular permeability

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular permeability pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDH5, KANK3, and SEPTIN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular permeability activity versus CDH5 in CCRCC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDH5 →	+0.562	+0.100	<.001	<.001	3	9
CCRCC	KANK3 →	+0.513	+0.100	<.001	<.001	3	9
CCRCC	SEPTIN4 →	+0.568	+0.116	<.001	<.001	3	8
BRCA	SOD3 →	+0.962	+0.067	<.001	<.001	3	8
BRCA	SSC5D →	+0.737	+0.038	<.001	<.001	3	8
HNSC	SYNPO →	+0.422	+0.051	.008	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043116 vs CDH5 — CCRCC

Explore this scatter interactively →