Negative regulation of vascular permeability

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular permeability pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB14, GET4, and SEMA4G, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular permeability activity versus RAB14 in URINARY_TRACT (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAB14 →	-0.713	-1.679	.005	.001	3	4
LUNG_SCLC	GET4 →	-0.613	-0.910	.001	.001	3	4
BLOOD_Leukemia	SEMA4G →	+0.805	+0.846	.001	.003	3	3
SOFT_TISSUE	OSBPL10 →	+2.529	+0.258	.008	.007	3	3
SOFT_TISSUE	H2BC5 →	-1.726	-0.245	<.001	.006	2	4
LIVER	EFS →	-0.048	-0.327	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043116 vs RAB14 — URINARY_TRACT

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