Regulation of vascular permeability

Across TCGA cell cohorts, RNA activity of the Regulation of vascular permeability pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP4B, KRT18, and PSMD13, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHMP4B grouped by Regulation of vascular permeability-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHMP4B →	-0.562	-0.504	<.001	.001	3	3
CNS	KRT18 →	-2.523	-0.424	<.001	.008	3	3
CNS	PSMD13 →	-0.409	-0.514	.002	.009	3	3
URINARY_TRACT	AFAP1 →	-3.400	-0.519	.006	.004	3	3
OVARY	IGFBP7 →	-2.736	-0.484	.008	.009	3	3
OVARY	ARHGEF10L →	-1.064	-0.548	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHMP4B by Regulation of vascular permeability activity — CNS

Explore this box plot interactively →