Regulation of vascular permeability

Across TCGA cell cohorts, RNA activity of the Regulation of vascular permeability pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SS18L1, RP1, and KLHDC8B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular permeability activity versus SS18L1 in LUNG_SCLC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SS18L1 →	-0.517	-0.872	.003	.004	3	4
KIDNEY	RP1 →	+1.772	+0.424	.004	<.001	3	4
CNS	KLHDC8B →	-1.418	-0.324	<.001	.002	3	4
KIDNEY	ANKS1A →	+1.205	+0.669	.002	<.001	3	4
URINARY_TRACT	PITPNA →	+0.643	+0.489	.002	.001	3	4
URINARY_TRACT	CERS4 →	-2.468	-0.512	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043114 vs SS18L1 — LUNG_SCLC

Explore this scatter interactively →