Receptor clustering

Across TCGA patient cohorts, RNA activity of the Receptor clustering pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYD, AIFM2, and SH3KBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor clustering activity versus DPYD in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DPYD →	+0.398	+0.024	.001	.004	3	5
BRCA	AIFM2 →	+0.395	+0.027	.002	<.001	3	5
BRCA	SH3KBP1 →	+0.281	+0.023	<.001	<.001	3	4
BRCA	SPTLC2 →	-0.303	-0.021	.009	.004	3	4
BRCA	TESPA1_S311 →	+0.542	+0.027	<.001	<.001	3	4
BRCA	TMEM87B →	-0.425	-0.017	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043113 vs DPYD — BRCA

Explore this scatter interactively →