Receptor clustering

Across TCGA patient cohorts, RNA activity of the Receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGLN, LMOD1, and IRAG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor clustering activity versus TAGLN in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TAGLN →	+1.709	+0.228	<.001	<.001	3	7
OV	LMOD1 →	+1.129	+0.190	<.001	<.001	3	7
OV	IRAG1 →	+1.436	+0.216	<.001	<.001	3	7
OV	ASPN →	+2.432	+0.215	<.001	<.001	3	6
OV	ACTA2 →	+2.266	+0.254	<.001	<.001	3	6
OV	CNRIP1 →	+0.995	+0.190	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043113 vs TAGLN — OV

Explore this scatter interactively →