Receptor clustering

Across TCGA cell cohorts, RNA activity of the Receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED27, CCDC88A, and TTBK2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor clustering activity versus MED27 in STOMACH (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MED27 →	-0.867	-0.148	.008	.008	3	10
LUNG_NSCLC_LUSC	CCDC88A →	-2.151	-0.163	<.001	<.001	3	9
LUNG_NSCLC_LUSC	TTBK2 →	-1.487	-0.181	.001	<.001	3	9
STOMACH	TJP3 →	+2.929	+0.153	<.001	.008	3	9
LUNG_NSCLC_LUSC	ADAP1 →	+2.657	+0.143	.001	.001	3	9
LIVER	CRB3 →	+3.223	+0.141	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043113 vs MED27 — STOMACH

Explore this scatter interactively →