Receptor clustering

Across TCGA cell cohorts, RNA activity of the Receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCAM, CD44, and NAA25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor clustering activity versus MCAM in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MCAM →	+2.739	+0.223	.002	.001	3	5
BLOOD_Leukemia	CD44 →	+1.949	+0.126	.002	.004	3	5
OESOPHAGUS	NAA25 →	-0.444	-0.199	.009	.006	3	4
LUNG_SCLC	CLIP4 →	+2.726	+0.319	<.001	<.001	3	4
LUNG_SCLC	DST →	+1.514	+0.189	.001	.004	3	4
LUNG_SCLC	H2AC19 →	+1.491	+0.239	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043113 vs MCAM — OVARY

Explore this scatter interactively →