Receptor metabolic process

Across TCGA patient cohorts, RNA activity of the Receptor metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF77, DHX35, and MPDZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor metabolic process activity versus ZNF77 in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF77 →	-0.415	-0.199	.001	.004	3	5
GBM	DHX35 →	-0.363	-0.227	<.001	<.001	3	4
GBM	MPDZ →	-0.536	-0.174	<.001	.001	3	4
GBM	LHX9 →	-0.686	-0.201	.006	.001	3	4
GBM	NFIB →	-1.147	-0.284	<.001	<.001	3	4
LUAD	NCAPD3 →	-0.472	-0.152	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043112 vs ZNF77 — GBM

Explore this scatter interactively →