Receptor metabolic process

Across TCGA cell cohorts, RNA activity of the Receptor metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF13A, BTN2A2, and SWAP70, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF13A grouped by Receptor metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KIF13A →	-1.170	-1.328	.004	.001	3	4
LUNG_NSCLC_LUAD	BTN2A2 →	-0.921	-1.011	.004	<.001	3	4
LUNG_NSCLC_LUAD	SWAP70 →	-0.547	-0.739	.006	.001	3	4
LUNG_NSCLC_LUAD	QSER1 →	-0.535	-1.025	.002	<.001	3	4
BLOOD_Leukemia	ZFYVE28 →	-1.726	-1.292	.001	.003	2	4
LUNG_NSCLC_LUSC	BTF3 →	-0.878	-1.298	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF13A by Receptor metabolic process activity — OVARY

Explore this box plot interactively →