Amino acid salvage

Across TCGA patient cohorts, RNA activity of the Amino acid salvage pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HROB, KNL1, and FANCA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid salvage activity versus HROB in PDAC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HROB →	+0.504	+0.122	<.001	.001	3	5
CCRCC	KNL1 →	+0.685	+0.230	<.001	<.001	3	5
PDAC	FANCA →	+0.551	+0.104	<.001	<.001	3	5
CCRCC	UBE2V1P13 →	+0.361	+0.199	<.001	<.001	3	5
BRCA	RAB8A →	+0.566	+0.078	<.001	.001	3	4
OV	EIPR1 →	+0.607	+0.159	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043102 vs HROB — PDAC

Explore this scatter interactively →