Amino acid salvage

Across TCGA cell cohorts, RNA activity of the Amino acid salvage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, PFKL, and ZNF219, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid salvage activity versus BIN2 in BLOOD_Lymphoma (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BIN2 →	-4.163	-1.551	.006	<.001	3	2
BLOOD_Lymphoma	PFKL →	+1.733	+1.551	.002	<.001	3	2
BLOOD_Lymphoma	ZNF219 →	+1.786	+1.551	.005	<.001	3	2
BLOOD_Lymphoma	TMEM154 →	-3.030	-1.646	<.001	.006	3	2
BLOOD_Lymphoma	SOX2 →	-2.440	-1.542	.003	.001	3	2
BLOOD_Lymphoma	RTL6 →	-2.675	-1.661	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043102 vs BIN2 — BLOOD_Lymphoma

Explore this scatter interactively →