Cellular metabolic compound salvage

Across TCGA patient cohorts, RNA activity of the Cellular metabolic compound salvage pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTHRC1, ARPC2, and TBC1D2B_S155, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular metabolic compound salvage activity versus CTHRC1 in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CTHRC1 →	+1.300	+0.046	<.001	<.001	3	7
GBM	ARPC2 →	+0.205	+0.042	<.001	<.001	3	6
GBM	TBC1D2B_S155 →	+0.401	+0.046	<.001	<.001	3	6
LUAD	SULF1 →	+0.795	+0.055	<.001	<.001	3	6
OV	C1R →	+0.643	+0.041	<.001	<.001	3	6
OV	FAP →	+1.164	+0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043094 vs CTHRC1 — OV

Explore this scatter interactively →