Cellular metabolic compound salvage

Across TCGA cell cohorts, RNA activity of the Cellular metabolic compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN3, ZNF134, and RAB11A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCN3 grouped by Cellular metabolic compound salvage-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCN3 →	-1.405	-1.069	.009	.002	3	4
URINARY_TRACT	ZNF134 →	-0.496	-1.509	.001	<.001	3	4
LIVER	RAB11A →	+0.798	+1.155	<.001	<.001	3	4
LIVER	ATP2A2 →	+0.793	+1.179	<.001	.004	3	4
LUNG_NSCLC_LUSC	C9orf85 →	+0.897	+1.411	.001	.002	3	3
LUNG_NSCLC_LUAD	PDE4D →	+1.347	+0.789	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCN3 by Cellular metabolic compound salvage activity — OVARY

Explore this box plot interactively →